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2.1.1 Lactic acid generation pathway 2.1.1.1 Lactic acid in RA pathology In RA synovial tissue, platelet-derived growth factors (PDGF), tumor necrosis factor (TNF), and pro-inflammatory mediators can transform resting FLS cells into an aggressive phenotype associated with glycolysis (RAFLS), known as the Warburg effect (Zhao et al., 2016)

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